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China’s NMPA perspective on the clinical performance of SARS-CoV-2 antigen test reagents

Isolation is really useful throughout acute an infection with SARS-CoV-2, the virus that causes COVID-19, however the length of infectiousness varies amongst particular person individuals. Fast antigen take a look at outcomes have been correlated with detection of viable virus (1-3) and may inform isolation steerage, however knowledge are restricted for the not too long ago emerged SARS-CoV-2 B.1.1.529 (Omicron) variant. On January 5, 2022, the Yukon-Kuskokwim Well being Company (YKHC) really useful that individuals with SARS-CoV-2 an infection isolate for 10 days after symptom onset (or, for asymptomatic individuals, 10 days after a constructive nucleic acid amplification or antigen take a look at consequence). Nevertheless, isolation may finish after 5-9 days if signs have been resolving or absent, fever was absent for ≥24 hours with out fever-reducing drugs, and an Abbott BinaxNOW COVID-19 Ag (BinaxNOW) speedy antigen take a look at consequence was damaging.

Antigen take a look at outcomes and related particular person traits have been analyzed amongst 3,502 infections reported to YKHC throughout January 1-February 9, 2022. After 5-9 days, 396 of 729 individuals evaluated (54.3%) had a constructive antigen take a look at consequence, with a declining proportion constructive over time. In a multivariable mannequin, a constructive antigen take a look at consequence was extra possible after 5 days in contrast with 9 days (adjusted odds ratio [aOR] = 6.39) or after symptomatic an infection (aOR = 9.63), and fewer possible after earlier an infection (aOR = 0.30), receipt of a major COVID-19 vaccination collection (aOR = 0.60), or after each earlier an infection and receipt of a major COVID-19 vaccination collection (aOR = 0.17). Antigen exams is likely to be a great tool to information suggestions for isolation after SARS-CoV-2 an infection. Through the 10 days after an infection, individuals is likely to be infectious to others and are really useful to INDICAID Rapid Antigen Test Instructions put on a well-fitting masks when round others, even when ending isolation after 5 days.

Since autumn 2020, speedy antigen exams (RATs) have been applied in a number of international locations as an necessary pillar of the nationwide testing technique to quickly display screen for infections on web site through the SARS-CoV-2 pandemic.

The present surge in an infection charges across the globe is pushed by the variant of concern (VoC) omicron (B.1.1.529). Right here, we evaluated the efficiency of 9 SARS-CoV-2 RATs in a single-centre laboratory examine. We examined a complete of 115 SARS-CoV-2 PCR-negative and 166 SARS-CoV-2 PCR-positive respiratory swab samples (101 omicron, 65 delta (B.1.617.2)) collected from October 2021 till January 2022 in addition to cell culture-expanded medical isolates of each VoCs. In an evaluation of the analytical sensitivity in medical specimen, the 50% restrict of detection (LoD50) ranged from 1.77 × 106 to 7.03 × 107 RNA copies subjected to the RAT for omicron in comparison with 1.32 × 105 to 2.05 × 106 for delta.

To attain constructive in these point-of-care exams, as much as 10-fold (LoD50) or 101-fold (LoD95) increased virus hundreds have been required for omicron- in comparison with delta-containing samples. The charges of true constructive take a look at outcomes for omicron samples within the highest virus load class (Ct values < 25) ranged between 31.four and 77.8%, whereas they dropped to 0-8.3% for samples with intermediate Ct values (25-30). Of observe, testing of expanded virus shares instructed a comparable RAT sensitivity of each VoCs, questioning the predictive worth of one of these in vitro-studies for medical efficiency. Given their significance for nationwide take a look at methods within the present omicron wave, consciousness should be elevated for the decreased detection price of omicron infections by RATs and a brief checklist of appropriate RATs that fulfill the minimal necessities of efficiency ought to be quickly disclosed.

The COVID-19 pandemic continues to unfold all around the world.

  1. Within the strategy of emergency use authorization, the Heart for Medical Gadget Analysis of the China Nationwide Medical Merchandise Administration issued ‘Key Factors of Technical Assessment for the Registration of SARS-CoV-2 Antigen/Antibody Detection Reagents’ because the steerage of registration of antigen and antibody take a look at reagents for the business.
  2. On this doc, medical analysis necessities of antigen detection reagents are elaborated. Primarily based on the Key Factors doc and the authors’ overview follow, this text explains the analysis strategies and necessities of medical efficiency of SARS-CoV-2 antigen-detecting speedy diagnostic exams, then analyzes the appliance eventualities and meant use of antigen detection reagents.
  3. The antigen-based speedy diagnostic take a look at (Ag-RDT) utilizing saliva specimens is quick, noninvasive, and appropriate for SARS-CoV-2 self-testing, in contrast to nasopharyngeal swab (NPS) testing.
  4. We evaluated a novel Beanguard gargle (BG)-based virus assortment methodology that may be utilized to Ag-RDT as a substitute for the present RT-PCR with an NPS for early prognosis of COVID-19.
  5. This medical trial comprised 102 COVID-19-positive sufferers hospitalized after a governmental screening course of and 100 wholesome people.
  6. Paired NPS and BG-based saliva specimens from COVID-19 sufferers and wholesome people have been analyzed utilizing NPS-RT-PCR, BG-RT-PCR, and BG-Ag-RDTs, whose diagnostic efficiency for detecting SARS-CoV-2 was in contrast.

 

BG-Ag-RDTs confirmed excessive sensitivity (97.8%) and specificity (100%) in 45 sufferers inside 6 days of sickness and detected all instances of SARS-CoV-2 Alpha and Delta variants.

In 11 asymptomatic energetic COVID-19 instances, each BG-Ag-RDTs and BG-RT-PCR confirmed sensitivities and specificities of 100%. Sensitivities of BG-Ag-RDT and BG-RT-PCR towards salivary viral detection have been extremely concordant, with no discrimination between symptomatic (97.0%), asymptomatic (100%), or SARS-CoV-2 variant (100%) instances.

The intermolecular interactions between SARS-CoV-2 spike proteins and truncated canavalin, an energetic ingredient from the bean extract (BE), have been noticed by way of physicochemical properties. The detachment of the SARS-CoV-2 receptor-binding area from hACE2 elevated because the BE focus elevated, permitting the discharge of the virus from hACE2 for early prognosis.Utilizing BG-based saliva specimens remarkably enhances the Ag-RDT diagnostic efficiency as a substitute for NPS and allows noninvasive, speedy, and correct COVID-19 self-testing and mass screening, supporting environment friendly COVID-19 administration

 

The goal of this examine was the direct detection of feline coronavirus by real-time PCR and by three totally different speedy immunochromatographic (RIM) exams detecting antigens in faecal samples of shelter cats. Primarily based on sensitivity and specificity calculated for every of the RIM exams, the utility of RIM exams was in contrast. Seventy faecal samples originating from shelter cats housed in quarantine have been examined. Out of 70 samples analyzed by real-time PCR, 44 (62.9%) have been constructive. Considerably extra cats (p < 0.05) examined constructive than damaging. Neither age nor intercourse of the cats performed a major position (p > 0.05) within the shedding standing of the virus.

Hepatitis B Surface Antigen (HBsAg) ELISA kit, Qualitative, 96 tests,

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Human Anti-Smith antigen (Sm) IgG ELISA kit, 96 tests, Quantitative

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Clostridium difficile Toxin/Toxoid A antigen ELISA kit, 96 tests, Quantitative

CDTA-010-96 Alpha Diagnostics 1 Kit 927.6 EUR

Human Anti-Smith antigen/RNP (Sm/RNP) IgG ELISA kit, 96 tests, Quantitative

3300-110-SRG Alpha Diagnostics 1 kit 708 EUR

Anthrax Protective Antigen 83 (PA83) Protein ELISA kit, 96 tests, Quantitative Kit

800-100-P83 Alpha Diagnostics 1 Kit 1365.6 EUR

Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 48 tests, Quantitative

AE-320800-48 Alpha Diagnostics 1 kit 1074 EUR

Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 96 tests, Quantitative

AE-320800-96 Alpha Diagnostics 1 kit 1804.8 EUR

West Nile Virus NS1 Protein (WNV-NS1) antigen ELISA kit, 96 tests, Quantitative

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Horse Anti-Anthrax Protective Antigen 83 (PA83) IgG ELISA kit, 96 tests, quantitative

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Human Anti-Anthrax Protective Antigen 83 (PA83) IgG ELISA kit, 96 tests, quantitative

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Sheep Anti-Anthrax Protective Antigen 83 (PA83) IgG ELISA kit, 96 tests, quantitative

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Camel Anti-Anthrax Protective Antigen 83 (PA83) IgG ELISA kit, 96 tests, quantitative

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Borrelia Afzelii Antigen

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Borrelia Garinii Antigen

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Borrelia Garinii Antigen

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Brucella Abortus Antigen

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Brucella Abortus Antigen

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Candida Albicans Antigen

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Candida Albicans Antigen

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Recombivirus PRRSV NP Type 1 antigen coated plates for ELISA (5x96 tests), Quantitative

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Recombivirus PRRSV NP Type 2 antigen coated plates for ELISA (5x96 tests), Quantitative

RV-400116-CP5 Alpha Diagnostics 1 kit 927.6 EUR

Canine Coronavirus Antigen

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Feline Calicivirus Antigen

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Helicobacter Pylori Antigen

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Helicobacter Pylori Antigen

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Campylobacter Jejuni Antigen

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Campylobacter Jejuni Antigen

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Recombivirus PRRSV NSP Type 1 antigen coated plates for ELISA (5x96 tests), Quantitative

RV-400136-CP5 Alpha Diagnostics 1 pk 927.6 EUR

Recombivirus PRRSV NSP Type 2 antigen coated plates for ELISA (5x96 tests), Quantitative

RV-400146-CP5 Alpha Diagnostics 1 kit 927.6 EUR

Chlamydia Trachomatis Antigen

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Neisseria Gonorrhoeae Antigen

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Mycoplasma Pneumoniae Antigen

MP901-1000 The Native Antigen Company 1.0 1019.75 EUR

Mycoplasma Pneumoniae Antigen

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Echovirus Antigen, Recombinant

REC31776-100 The Native Antigen Company 0.1 279.4 EUR

Echovirus Antigen, Recombinant

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Trichomonas Vaginalis Antigen

TV01-1000 The Native Antigen Company 1.0 424.9 EUR

Mouse Anti-Anthrax Protective Antigen 83 (PA83) Ig?s ELISA kit, 96 tests, Quantitative

900-100-83T Alpha Diagnostics 1 Kit 927.6 EUR

Rabbit Anti-Anthrax Protective Antigen 83 (PA83) Ig?s ELISA kit, 96 tests, quantitative

900-120-83T Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Anthrax Protective Antigen 83 (PA83) Ig?s ELISA kit, 96 tests, quantitative

900-150-83T Alpha Diagnostics 1 Kit 927.6 EUR

Human Anti-Anthrax Protective Antigen 83 (PA83) Ig?s ELISA kit, 96 tests, quantitative

900-160-83T Alpha Diagnostics 1 Kit 927.6 EUR

Human Anti-Proliferating Cell Nuclear Antigen (PCNA) IgG ELISA kit, 96 tests, Quantitative

5025 Alpha Diagnostics 1 Kit 1000.8 EUR

Monkey Anti-Proliferating Cell Nuclear Antigen (PCNA) IgG ELISA kit, 96 tests, Quantitative

5030 Alpha Diagnostics 1 Kit 1000.8 EUR

Echinococcus Granulosus Antigen

NAT41602-100 The Native Antigen Company 0.1 395.28 EUR

Echinococcus Granulosus Antigen

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Enterovirus Antigen, Recombinant

REC31772-100 The Native Antigen Company 0.1 279.4 EUR

Enterovirus Antigen, Recombinant

REC31772-500 The Native Antigen Company 0.5 1053.23 EUR

Rat Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgG ELISA kit, 96 tests, quantitative

4270 Alpha Diagnostics 1 Kit 854.4 EUR

Rat Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative

4270-30-IGA Alpha Diagnostics 1 Kit 1074 EUR

Cytomegalovirus Purified Antigen

CMV-HP-100 The Native Antigen Company 0.1 321.89 EUR

Cytomegalovirus Purified Antigen

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Cytomegalovirus Purified Antigen

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Astrovirus Antigen (Type 1)

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Astrovirus Antigen (Type 1)

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Yersinia pestis V antigen

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Yersinia pestis V antigen

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Canine Herpes Virus Antigen

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G. pig Anti-Anthrax Protective Antigen 83 (PA83) Ig?s ELISA kit, 96 tests, quantitative

900-140-83T Alpha Diagnostics 1 Kit 927.6 EUR

Human Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative

4200-30-IGA Alpha Diagnostics 1 Kit 1074 EUR

Mouse Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgG ELISA kit, 96 tests, quantitative

4210 Alpha Diagnostics 1 Kit 854.4 EUR

Mouse Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative

4210-30-IGA Alpha Diagnostics 1 Kit 1074 EUR

Human Anti-Hepatitis B Surface Antigen IgG (anti-HBsAg) ELISA kit, Quantitative, 96 tests

4220-AHB Alpha Diagnostics 1 Kit 781.2 EUR

Mouse CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4/CD152) ELISA Kit, 96 tests, quantitative

210-220-CA4 Alpha Diagnostics 1 Kit 927.6 EUR

Human CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4/CD152) ELISA Kit, 96 tests, quantitative

210-230-CA4 Alpha Diagnostics 1 Kit 1220.4 EUR

Recombivirus PRRSV NP Type 1+2 antigen coated plates for ELISA (5x96 tests), Quantitative

RV-400126-CP5 Alpha Diagnostics 1 pk 927.6 EUR

Recombivirus Foot and mouth disease virus 3AB antigen coated plates for ELISA (5x96 tests)

RV-400771-CP5 Alpha Diagnostics 1 pk 927.6 EUR

Recombivirus 1+2+3 E2 Protein antigen coated plates for ELISA (5x96 tests), Quantitative

RV-500181-CP5 Alpha Diagnostics 1 pk 927.6 EUR

Canine Adenovirus 1 Antigen

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Canine Adenovirus 2 Antigen

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Toxoplasma gondii IgM antigen

TG-IgM-100 The Native Antigen Company 0.1mg 139.86 EUR

Toxoplasma gondii IgM antigen

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Canine Distemper Virus Antigen

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Rabbit Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgG ELISA kit, 96 tests, quantitative

4240 Alpha Diagnostics 1 Kit 854.4 EUR

Monkey Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative

4250-30-IGA Alpha Diagnostics 1 Kit 1220.4 EUR

Recombivirus PRRSV NSP Type 1+2 antigen coated plates for ELISA (5x96 tests), Quantitative

RV-400156-CP5 Alpha Diagnostics 1 pk 927.6 EUR

G. pig Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgG ELISA kit, 96 tests, quantitative

4260 Alpha Diagnostics 1 Kit 854.4 EUR

SR Poly Caspase Kit 25 Tests

SR100-1 Cell Technology 25 Tests 205 EUR

Canine Parainfluenza Virus Antigen

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Feline Panleukopenia Virus Antigen

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Norovirus GII.4 VP1 Antigen

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Norovirus GII.4 VP1 Antigen

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Norovirus GII.4 VP1 Antigen

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Cytomegalovirus Cell Lysate Antigen

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Cytomegalovirus Cell Lysate Antigen

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Rat Rena-strip Kit, 25 tests

R-RENA-LF-025 BioAssayWorks 25 tests 617.3 EUR

Feline Viral Rhinotracheitis Antigen

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Mouse Anti-Anthrax Protective Antigen 83 (PA83) IgG-specific) ELISA kit, 96 tests, quantitative

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Herpes Simplex Virus 1 Antigen

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Herpes Simplex Virus 1 Antigen

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Herpes Simplex Virus 2 Antigen

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Herpes Simplex Virus 2 Antigen

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Human Rena-strip Kit, 25 tests

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Ross River Virus Recombinant Antigen

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Ross River Virus Recombinant Antigen

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Canine Adenovirus 1 and 2 Antigen

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Hepatitis B Virus E Antigen (HBeAg)

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Hepatitis B Virus E Antigen (HBeAg)

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Hepatitis B Virus Core Antigen (HBcAg)

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Hepatitis C Virus Core Antigen (HCcAg)

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Hepatitis C Virus Core Antigen (HCcAg)

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Feline Infectious Peritonitis Virus Antigen

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Herpes Simplex Virus 1 Lysate Antigen

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Herpes Simplex Virus 2 Lysate Antigen

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Toxoplasma gondii IgG antigen, RH strain

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Toxoplasma gondii IgG antigen, RH strain

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Toxoplasma gondii IgG antigen, RH strain

TG-IgG-5000 The Native Antigen Company 5.0 mg 1436.48 EUR

Legionella pneumophila antigen (native extract)

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Human Anti-Epstein Barr Virus (EBV/HHV-4) early antigen (EA) IgA ELISA Kit, 96 tests, quantitative

510-215-HEA Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) early antigen (EA) IgG ELISA Kit, 96 tests, quantitative

510-220-HEG Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) early antigen (EA) IgM ELISA Kit, 96 tests, quantitative

510-225-HEM Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) Early antigen (D) IgG ELISA Kit, 96 tests, quantitative

510-245-EDG Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) Early antigen (D) IgM ELISA Kit, 96 tests, quantitative

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Human Anti-Epstein Barr Virus (EBV/HHV-4) Early antigen (D) IgA ELISA Kit, 96 tests, quantitative

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Humanized/Human Anti-Anthrax Protective Antigen 83 (PA83) IgG activity ELISA kit, 96 tests, quantitative

900-155-HPA Alpha Diagnostics 1 Kit 1365.6 EUR

Human Anti-Meningitis B Neisserial Heparin Binding Antigen (NHBA) IgG ELISA kit, 96 tests, quantitative

600-920-HHG Alpha Diagnostics 1 kit 1000.8 EUR

Mouse Anti-Meningitis B Neisserial Heparin Binding Antigen (NHBA) IgG ELISA kit, 96 tests, quantitative

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Rabbit Anti-Meningitis B Neisserial Heparin Binding Antigen (NHBA) IgG ELISA kit, 96 tests, quantitative

600-970-RHG Alpha Diagnostics 1 kit 1000.8 EUR

Streptococcus Pneumoniae Antigen, Native Extract

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Leptospira Biflexa Antigen (Strain Patoc 1)

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Leptospira Biflexa Antigen (Strain Patoc 1)

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Recombivirus BVDV 1 Erns 1 Erns (BVDV1-Erns) Protein antigen coated plates for ELISA (5x96 tests)

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Dual Sensor Casp 1 &MMP 25 Tests

MITCAP600-1 Cell Technology 25 Tests 182.5 EUR

Human Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgM ELISA kit, 96 tests, quantitative

4305 Alpha Diagnostics 1 Kit 927.6 EUR

Mouse Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgG ELISA kit, 96 tests, quantitative

4310 Alpha Diagnostics 1 Kit 927.6 EUR

Mouse Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgM ELISA kit, 96 tests, quantitative

4315 Alpha Diagnostics 1 Kit 927.6 EUR

Poly Casp FAM-VAD-FMK 25 Tests

FAM100-1 Cell Technology 25 Tests 205 EUR

Dual Sensor Poly Casp &MMP 25 Tests

MITCAP100-1 Cell Technology 25 Tests 182.5 EUR

Human Anti-H. Influenzae B (Hib) polyribosyl phosphate (PRP) antigen (vaccine) ELISA Kit, 96 tests, Quantitative

980-HIB-AG1 Alpha Diagnostics 1 Kit 1448.4 EUR

Rabbit Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgG ELISA kit, 96 tests, quantitative

4340 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgG ELISA kit, 96 tests, quantitative

4350 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S1 (HB-Pre-S1) IgM ELISA kit, 96 tests, quantitative

4355 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S2 (HB-Pre-S2) IgG ELISA kit, 96 tests, quantitative

4450 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S2 (HB-Pre-S2) IgM ELISA kit, 96 tests, quantitative

4455 Alpha Diagnostics 1 Kit 927.6 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) virus capsid antigen (VCA) IgA ELISA Kit, 96 tests, quantitative

510-230-HEA Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) virus capsid antigen (VCA) IgG ELISA Kit, 96 tests, quantitative

510-235-HEG Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) virus capsid antigen (VCA) IgM ELISA Kit, 96 tests, quantitative

510-240-HEM Alpha Diagnostics 1 Kit 708 EUR

FAM-FMK - Caspase 8 Detection - 25 Tests

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FAM-FMK - Caspase 9 Detection - 25 Tests

FAM400-1 Cell Technology 25 Tests 215 EUR

FAM-FMK - Caspase 6 Detection - 25 Tests

FAM500-1 Cell Technology 25 Tests 225 EUR

FAM-FMK - Caspase 1 Detection - 25 Tests

FAM600-1 Cell Technology 25 Tests 215 EUR

FAM-FMK - Caspase 2 Detection - 25 Tests

FAM700-1 Cell Technology 25 Tests 225 EUR

FAM-FMK - Caspase 10 Detection - 25 Tests

FAM800-1 Cell Technology 25 Tests 205 EUR

Free Chlorine Reagent set (25 tests) - PK25

HI-701-25 Scientific Laboratory Supplies PK25 12.15 EUR

Mouse Anti-Hepatitis B Surface Antigen Antibody (1834)

MAB12230-100 The Native Antigen Company 0.1 278.11 EUR

Mouse Anti-Hepatitis B Surface Antigen Antibody (1837)

MAB12231-100 The Native Antigen Company 0.1 278.11 EUR

Mouse Anti-Hepatitis B Surface Antigen Antibody (1838)

MAB12232-100 The Native Antigen Company 0.1 278.11 EUR

Total Chlorine Reagent set (25 tests) - PK25

HI-711-25 Scientific Laboratory Supplies PK25 17.55 EUR

Vaccigel Anthrax Protective Antigen 83 (PA83) Protein Adsorbed on Alum, ELISA kit for 48 tests, Quantitative Kit

VAC-P83-50 Alpha Diagnostics 1 Kit 1448.4 EUR

ExoBrite™ 410/450 CD9 Flow Antibody (25 tests)

P003-410-125 Biotium 1UL 172 EUR

ExoBrite™ 490/515 CD9 Flow Antibody (25 tests)

P003-490-125 Biotium 1UL 172 EUR

ExoBrite™ 560/585 CD9 Flow Antibody (25 tests)

P003-560-125 Biotium 1UL 172 EUR

ExoBrite™ 650/665 CD9 Flow Antibody (25 tests)

P003-650-125 Biotium 1UL 165 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1892)

MAB12226-100 The Native Antigen Company 0.1 198.28 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1893)

MAB12227-100 The Native Antigen Company 0.1 278.11 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1894)

MAB12228-100 The Native Antigen Company 0.1 278.11 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgA ELISA Kit, 96 tests, quantitative

510-200-HEA Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgG ELISA Kit, 96 tests, quantitative

510-205-HEG Alpha Diagnostics 1 Kit 708 EUR

Human Anti-Epstein Barr Virus (EBV/HHV-4) Nuclear Antigen 1 (EBNA-1) IgM ELISA Kit, 96 tests, quantitative

510-210-HEM Alpha Diagnostics 1 Kit 708 EUR

ExoBrite™ R-PE CD9 Flow Antibody (25 tests)

P003-RPE-125 Biotium 1UL 172 EUR

ExoBrite™ 410/450 CD63 Flow Antibody (25 tests)

P004-410-125 Biotium 1UL 172 EUR

ExoBrite™ 490/515 CD63 Flow Antibody (25 tests)

P004-490-125 Biotium 1UL 172 EUR

ExoBrite™ 560/585 CD63 Flow Antibody (25 tests)

P004-560-125 Biotium 1UL 172 EUR

ExoBrite™ 410/450 CD81 Flow Antibody (25 tests)

P005-410-125 Biotium 1UL 172 EUR

ExoBrite™ 490/515 CD81 Flow Antibody (25 tests)

P005-490-125 Biotium 1UL 172 EUR

ExoBrite™ 560/585 CD81 Flow Antibody (25 tests)

P005-560-125 Biotium 1UL 172 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132)

MAB12298-100 The Native Antigen Company 0.1 279.4 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132)

MAB12298-500 The Native Antigen Company 0.5 701.72 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133)

MAB12299-100 The Native Antigen Company 0.1 279.4 EUR

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133)

MAB12299-500 The Native Antigen Company 0.5 701.72 EUR

Human Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgG ELISA kit (for vaccinated samples), 96 tests, quantitative

4200 Alpha Diagnostics 1 Kit 854.4 EUR

Human Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgM ELISA kit (for vaccinated samples), 96 tests, quantitative

4205 Alpha Diagnostics 1 Kit 854.4 EUR

ExoBrite™ R-PE CD63 Flow Antibody (25 tests)

P004-RPE-125 Biotium 1UL 172 EUR

ExoBrite™ R-PE CD81 Flow Antibody (25 tests)

P005-RPE-125 Biotium 1UL 172 EUR

ExoBrite™ 680/700 CD9 Western Antibody (25 tests)

P003-680-250 Biotium 1UL 204 EUR

ExoBrite™ 770/800 CD9 Western Antibody (25 tests)

P003-770-250 Biotium 1UL 204 EUR

Rabbit Anti-Hepatitis B Surface Antigen Pres-S1+2 (HB-Pre-S1+2) IgG ELISA kit, 96 tests, quantitative

4540 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S1+2 (HB-Pre-S1+2) IgG ELISA kit, 96 tests, quantitative

4550 Alpha Diagnostics 1 Kit 927.6 EUR

Monkey Anti-Hepatitis B Surface Antigen Pres-S1+2 (HB-Pre-S1+2) IgM ELISA kit, 96 tests, quantitative

4555 Alpha Diagnostics 1 Kit 927.6 EUR

ExoBrite™ 680/700 CD63 Western Antibody (25 tests)

P004-680-250 Biotium 1UL 204 EUR

ExoBrite™ 770/800 CD63 Western Antibody (25 tests)

P004-770-250 Biotium 1UL 204 EUR

ExoBrite™ 680/700 CD81 Western Antibody (25 tests)

P006-680-250 Biotium 1UL 204 EUR

ExoBrite™ 770/800 CD81 Western Antibody (25 tests)

P006-770-250 Biotium 1UL 204 EUR

Dual Sensor Casp 3/7 &MMP 25 Tests

MITCAP200-1 Cell Technology 25 Tests 182.5 EUR

Casp 3/7 FAM-DEVD-FMK 25 Tests

FAM200-1 Cell Technology 25 Tests 205 EUR

ExoBrite™ 770/800 Calnexin Western Antibody (25 tests)

P007-770-250 Biotium 1UL 204 EUR

Nori® Human CRP POCT Systems-25 Tests

GR220008 Genorise Scientific 25 Tests 299 EUR

Nori® Human ANP POCT Systems-25 Tests

GR220010 Genorise Scientific 25 Tests 618 EUR

Nori® Human ST2 POCT Systems-25 Tests

GR220016 Genorise Scientific 25 Tests 618 EUR

Nori® Feline ST2 POCT Systems-25 Tests

GR222016 Genorise Scientific 25 Tests 618 EUR

Nori® Equine CRP POCT Systems-25 Tests

GR223008 Genorise Scientific 25 Tests 299 EUR

Nori® Equine ANP POCT Systems-25 Tests

GR223010 Genorise Scientific 25 Tests 618 EUR

Nori® Equine ST2 POCT Systems-25 Tests

GR223016 Genorise Scientific 25 Tests 618 EUR

Nori® Human GPBB POCT Systems-25 Tests

GR220009 Genorise Scientific 25 Tests 618 EUR

Nori® Human MMP2 POCT Systems-25 Tests

GR220017 Genorise Scientific 25 Tests 618 EUR

Nori® Canine CRP POCT Systems-25 Tests

GR221008 Genorise Scientific 25 Tests 299 EUR

Nori® Canine ANP POCT Systems-25 Tests

GR221010 Genorise Scientific 25 Tests 618 EUR

Nori® Canine ST2 POCT Systems-25 Tests

GR221016 Genorise Scientific 25 Tests 618 EUR

Nori® Feline CRP POCT Systems-25 Tests

GR222008 Genorise Scientific 25 Tests 299 EUR

Nori® Feline ANP POCT Systems-25 Tests

GR222010 Genorise Scientific 25 Tests 618 EUR

Nori® Feline MMP2 POCT Systems-25 Tests

GR222017 Genorise Scientific 25 Tests 618 EUR

Nori® Equine GPBB POCT Systems-25 Tests

GR223009 Genorise Scientific 25 Tests 618 EUR

Nori® Equine MMP2 POCT Systems-25 Tests

GR223017 Genorise Scientific 25 Tests 618 EUR

Nori® Human PAPPA POCT Systems-25 Tests

GR220014 Genorise Scientific 25 Tests 618 EUR

Nori® Human sPLA2 POCT Systems-25 Tests

GR220018 Genorise Scientific 25 Tests 618 EUR

Nori® Canine GPBB POCT Systems-25 Tests

GR221009 Genorise Scientific 25 Tests 618 EUR

Nori® Canine MMP2 POCT Systems-25 Tests

GR221017 Genorise Scientific 25 Tests 618 EUR

Nori® Feline GPBB POCT Systems-25 Tests

GR222009 Genorise Scientific 25 Tests 618 EUR

Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag

REC32027-100 The Native Antigen Company 0.1 326.34 EUR

Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag

REC32027-500 The Native Antigen Company 0.5 1386.95 EUR

Nori® Feline sPLA2 POCT Systems-25 Tests

GR222018 Genorise Scientific 25 Tests 618 EUR

Nori® Equine PAPPA POCT Systems-25 Tests

GR223014 Genorise Scientific 25 Tests 618 EUR

Nori® Equine sPLA2 POCT Systems-25 Tests

GR223018 Genorise Scientific 25 Tests 618 EUR

Nori® Human MyBPC3 POCT Systems-25 Tests

GR220012 Genorise Scientific 25 Tests 618 EUR

Nori® Canine PAPPA POCT Systems-25 Tests

GR221014 Genorise Scientific 25 Tests 618 EUR

Nori® Canine sPLA2 POCT Systems-25 Tests

GR221018 Genorise Scientific 25 Tests 618 EUR

Nori® Feline PAPPA POCT Systems-25 Tests

GR222014 Genorise Scientific 25 Tests 618 EUR

Mouse IL-25 ELISA Kit, 96 tests, Quantitative

MIL-025-170 Alpha Diagnostics 1 kit 607.2 EUR

Nori® Equine MyBPC3 POCT Systems-25 Tests

GR223012 Genorise Scientific 25 Tests 618 EUR

Nori® Canine MyBPC3 POCT Systems-25 Tests

GR221012 Genorise Scientific 25 Tests 618 EUR

Nori® Feline MyBPC3 POCT Systems-25 Tests

GR222012 Genorise Scientific 25 Tests 618 EUR

Nori® Human Copeptin POCT Systems-25 Tests

GR220015 Genorise Scientific 25 Tests 618 EUR

Nori® Equine Copeptin POCT Systems-25 Tests

GR223015 Genorise Scientific 25 Tests 618 EUR

 

The sensitivity of the RIM exams was discovered to be at low (<35%; RIM exams A and C) to passable stage (>50%, RIM take a look at B). The variety of virus particles decided by real-time RT-PCR evaluation didn’t considerably correlate with the outcomes detected by any of the RIM exams (p > 0.05). The outcomes of this examine point out  that the usage of speedy antigen RIM exams in routine screening of FCoV shedding standing in shelter cats is restricted because of the prevalence of a excessive variety of false damaging outcomes.

 

 

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